Publications

Multi-Center Assessment of Infiltration Rates in FDG-PET/CT scans: Detection, Incidence, and Contributing Factors

“Since infiltrations can resolve during uptake and as the standard imaging FOV does not always capture the injection site, many infiltrations may go undetected. Infiltrations result in underestimated SUVs that can impact patient care emphasizing that it is important to monitor injection quality. Thus, identifying contributing factors associated with infiltrations may help stimulate quality improvements, reduce infiltration rates, and potentially improve patient care.”
Full Text

Novel Method to Detect and Characterize F-18 FDG Infiltrations in PET Injections: A Single Institution Experience

“Even when the injection site was out of the field of view, the time–activity curves could still detect and characterize infiltration. Our initial experience showed that the quality assurance information obtained from the device helped reduce the rate and severity of infiltration.” Full Text

Prolonged Venous Stasis: Invisible Intravenous FDG Infiltrations and Potential Negative Implications in PET/CT Examination

Two presentations at the SNMMI annual meeting discuss results from using the Lucerno system at Saint Louis University, with abstracts published on
Prolonged Venous Stasis and
a Pilot Quality Improvement Study .

Towards real-time topical detection and characterization of FDG dose infiltration prior to PET imaging

“Topical sensors applied near the injection site provide dynamic information from the time of FDG administration through the uptake period and may be useful in detecting infiltrations regardless of PET image field of view. This dynamic information may also complement the static PET image to better characterize the true extent of infiltrations.” Full Text (subscription required).

A Novel method for Whole-body dynamic imaging using Continuous Bed Motion PET/CT with non-invasive estimation of arterial input function using an external radiation detector device

“Further development of this technique may result in routine use of dynamic PET imaging to obtain improved quantitative imaging and more robust data comparison between patients.” Full Text

Non-invasive input function measurement using a modular detector device

“The presented device from Lucerno Dynamics, LLC, shows potential for use as a non-invasive method for determining arterial input functions for dynamic PET studies. This system may also obviate the need for “on the bed” injections and long 1 hour acquisitions to obtain image derived input functions. Further analysis is required to compare these methods with arterial blood sampling techniques.” Full Text