Publications

Assessing and reducing PET radiotracer infiltration rates: a single center experience in injection quality monitoring methods and quality improvement

“Developing a quality improvement plan and monitoring PET injections can lead to reduced infiltration rates. No significant correlation between reference SUVs and injection score provides evidence that determination of infiltration based on PET images alone may be limited. Results also indicate that the number of infiltrated PET injections is under-reported.” Full Text

Classification of Infiltrated Injections During PET/CT Imaging Applying Deep Learning Technique

“Deep learning techniques have been found to perform extremely well in classification tasks in recent years. Use of TACs obtained from sensors to identify and classify infiltrations is also a very recent approach in PET dose infiltration research. Combination of both these techniques is a novel approach which may play a significant role in classifying infiltrated injection or identifying good injections.” Full Text

Quality Improvement Initiatives to Assess and Improve PET/CT FDG Injection Infiltration Rates in Multiple Centers

“A QI approach with new technology can help centers measure infiltration rates, determine associative factors, implement interventions, and improve/sustain injection quality. Since PET/CT images help guide patient management, monitoring and improving radiotracer injection quality is important.” Full Text

A Retrospective Study of Physiologic Markers to Assess Radiopharmaceutical Infiltration Compared to External Injection Monitoring

“External injection monitoring seems to be the most reliable method for assessing PET radiopharmaceutical injection quality for individual patients.” Full Text

Use of a PACS Integrated Injection Monitoring Device to Increase Injection Quality and Infiltration Awareness

“Access to injection monitoring with PACS integration can lead to significant increases in radiology reporting of injection quality both to confirm good quality, and to indicate when an injection may have been compromised.” Full Text

Development of a Quantitatively-Based 18F-FDG Infiltration Classifier of Topically Applied Sensor Readings

“Preliminary findings suggest that this classifier, calibrated using quantitative static PET measurements, dramatically improves infiltration severity classification compared to qualitative image analysis.” Full Text

Collection of Real-Time Data with a Modular Detector System to Assess Injection Quality

“An external detector device may be used to ascertain that an injection is sufficient within only a 60-second acquisition.” Full Text (subscription required).

Technical Note: Characterization of technology to detect residual injection site radioactivity

“The performance of the sensor was adequate for identification of excessive residual activity at an injection site. Its ability to provide feedback may be useful as a quality control measure for nuclear medicine injections.” Full Text

Nuclear Rheumatology? An initial investigation into quantification of arthritis-induced inflammation

Josh Knowland of Lucerno Dynamics delivered an oral presentation on quantification and monitoring of RA disease progression with simple topical detectors during SNMMI 2019 mid-winter meeting in California.

Usefulness of Topically Applied Sensors to Assess the Quality of 18F-FDG Injections and Validation Against Dynamic Positron Emission Tomography (PET) Images

“Since the quality and quantification of PET/CT studies are of clinical importance, sensor measurements acquired during the FDG uptake may prove to be a useful quality control measure to reduce infiltration rates and potentially improve patient care.” Full Text

2018 SNMMI Highlights Lecture: General Nuclear Medicine

In the October 1, 2018 JNM the SNMMI Annual Meeting Highlights Lecture is featured in an article. Two of the 12 most significant General Nuclear Medicine presentations during the 2018 SNMMI Annual Meeting were Lucerno presentations regarding our Multi-center Quality Improvement Project. Dr. Jacene’s selection of these two presentations suggests the importance of the topic and the findings.

Scintillating fiber measures radiotracer concentration in blood

Physics World published a research update news story on the 8/23/18 AIF article, after interviewing Lucerno co-founder Josh Knowland.